When I've taken Primero Plus they do not stop between Melaque and Puerto Vallarta Centro or the Bus Station. They wouldn't let me off at the airport despite driving right by. I think the number of buses varies with which day of the week it is.
I just picked a random day and it appears there is one at 11:50 leaving Melaque, but arrives there at 4:40pm
https://viaje.primeraplus.com.mx/search/t-melaque-melaque/t-puerto-vallarta-central/31-mar-21/p/A1/departures/primera-plus
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